Article
HIV-1 clade D is associated with increased rates of CD4 decline in a Kenyan cohort.
PloS one - 1 Jan 2012
McKinnon Lyle R, Nagelkerke Nico J, Kaul Rupert, Shaw Souradet Y, Capina Rupert, Luo Ma, Kariri Anthony, Apidi Winnie, Kimani Makobu, Wachihi Charles, Jaoko Walter, Anzala A Omu, Kimani Joshua, Ball T Blake, Plummer Francis A
Abstract excerpt
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985-2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This...
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