Article
Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess.
Endocrinology - 1 Apr 2010
Peltoketo Hellevi, Strauss Leena, Karjalainen Riikka, Zhang Meilin, Stamp Gordon W, Segaloff Deborah L, Poutanen Matti, Huhtaniemi Ilpo T
Abstract excerpt
Strong gain-of-function mutations have not been identified in humans in the FSH receptor (FSHR), whereas such mutations are common among many other G protein-coupled receptors. In order to predict consequences of such mutations on humans, we first identified constitutively activated mutants of the mouse (m) Fshr and then expressed them under the human anti-Müllerian hormone promoter in transgenic mice or created...
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