Article
Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excess.
Endocrinology - 1 Apr 2010
Peltoketo Hellevi, Strauss Leena, Karjalainen Riikka, Zhang Meilin, Stamp Gordon W, Segaloff Deborah L, Poutanen Matti, Huhtaniemi Ilpo T
Abstract excerpt
Strong gain-of-function mutations have not been identified in humans in the FSH receptor (FSHR), whereas such mutations are common among many other G protein-coupled receptors. In order to predict consequences of such mutations on humans, we first identified constitutively activated mutants of th...
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