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Article

Evolutionary rate covariation in meiotic proteins results from fluctuating evolutionary pressure in yeasts and mammals.

Genetics - 1 Feb 2013

Clark Nathan L, Alani Eric, Aquadro Charles F

Abstract excerpt

Evolutionary rates of functionally related proteins tend to change in parallel over evolutionary time. Such evolutionary rate covariation (ERC) is a sequence-based signature of coevolution and a potentially useful signature to infer functional relationships between proteins. One major hypothesis to explain ERC is that fluctuations in evolutionary pressure acting on entire pathways cause parallel rate changes for...

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Identifiers

PMID: 23183665
DOI: 10.1534/genetics.112.145979
PMCID: PMC3567741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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