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Article

The role of accessory proteins in the replication of feline infectious peritonitis virus in peripheral blood monocytes.

Veterinary microbiology - 23 Mar 2013

Dedeurwaerder Annelike, Desmarets Lowiese M, Olyslaegers Dominique A J, Vermeulen Ben L, Dewerchin Hannah L, Nauwynck Hans J

Abstract excerpt

The ability to productively infect monocytes/macrophages is the most important difference between the low virulent feline enteric coronavirus (FECV) and the lethal feline infectious peritonitis virus (FIPV). In vitro, the replication of FECV in peripheral blood monocytes always drops after 12h post inoculation, while FIPV sustains its replication in the monocytes from 45% of the cats. The accessory proteins of...

Topics

Animals
Cat Diseases
Cats
Cell Line
Coronavirus Infections
Coronavirus, Feline
Leukocytes, Mononuclear
Mutation
Nucleocapsid Proteins
Open Reading Frames
Viral Regulatory and Accessory Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virulence

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 23182908
DOI: 10.1016/j.vetmic.2012.10.032
PMCID: PMC7117191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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