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Article

Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein.

Journal of virology - 1 Nov 2005

Rottier Peter J M, Nakamura Kazuya, Schellen Pepijn, Volders Haukeline, Haijema Bert Jan

Abstract excerpt

In feline coronavirus (FCoV) pathogenesis, the ability to infect macrophages is an essential virulence factor. Whereas the low-virulence feline enteric coronavirus (FECV) isolates primarily replicate in the epithelial cells of the enteric tract, highly virulent feline infectious peritonitis virus (FIPV) isolates have acquired the ability to replicate efficiently in macrophages, which allows rapid dissemination of...

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Identifiers

PMID: 16254347
DOI: 10.1128/JVI.79.22.14122-14130.2005
PMCID: PMC1280227

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Source receipt: pubmed, retrieved 7 Sept 2026.

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