The vif gene is essential for efficient replication of caprine arthritis encephalitis virus in goat synovial membrane cells and affects the late steps of the virus replication cycle.

doi:10.1128/JVI.69.6.3247-3257.1995

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Article

The vif gene is essential for efficient replication of caprine arthritis encephalitis virus in goat synovial membrane cells and affects the late steps of the virus replication cycle.

Journal of virology - 1 Jun 1995

Harmache A, Bouyac M, Audoly G, Hieblot C, Peveri P, Vigne R, Suzan M

Abstract excerpt

Complex retrovirus genomes contain a variable number of accessory genes, among which is the vif gene. We investigated in vitro the role of the vif gene of caprine arthritis encephalitis virus (CAEV) by studying the phenotype of five vif mutants after infection of primary goat synovial membrane (GSM) cells and blood-derived monocytes/macrophages. Any deletion introduced into the vif gene resulted in slow and low...

Topics

Amino Acid Sequence
Animals
Arthritis-Encephalitis Virus, Caprine
Base Sequence
Cells, Cultured
Cloning, Molecular
DNA Primers
Genes, vif
Genetic Complementation Test
Goats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

RNA, Viral

Sequence Homology, Amino Acid

Synovial Membrane

Transcription, Genetic

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 7745671
DOI: 10.1128/JVI.69.6.3247-3257.1995
PMCID: PMC189035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7745671-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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