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Article

Protein C-terminal variations impact proteostasis.

Nature communications - 3 Feb 2026

Chu Ching-Yu, Hsu Shu-Yu, Yeh Chi-Wei, Yeh Kun-Hai, Wang Li-Chin, Lee Lo-Tung, Chen Shu-Chuan, Yu Chen-Hsin, Yen Hsueh-Chi S

Abstract excerpt

Protein C-termini can vary due to errors or programmed regulation, contributing to proteome diversity, yet their impact on the proteome remains poorly understood. Although aberrant C-termini are often linked to protein degradation, it is unclear if this holds true universally. In this study, we examine how C-terminal variations-arising from disease-associated nonstop mutations, alternative splicing, and...

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Identifiers

PMID: 41634034
DOI: 10.1038/s41467-026-68979-z
PMCID: PMC12976096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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