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Article

Sitosterolemia: Twenty Years of Discovery of the Function of ABCG5ABCG8.

International journal of molecular sciences - 5 Mar 2021

Williams Kori, Segard Allison, Graf Gregory A

Abstract excerpt

Sitosterolemia is a lipid disorder characterized by the accumulation of dietary xenosterols in plasma and tissues caused by mutations in either ABCG5 or ABCG8. ABCG5 ABCG8 encodes a pair of ABC half transporters that form a heterodimer (G5G8), which then traffics to the surface of hepatocytes and enterocytes and promotes the secretion of cholesterol and xenosterols into the bile and the intestinal lumen. We...

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Identifiers

PMID: 33807969
DOI: 10.3390/ijms22052641
PMCID: PMC7961684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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