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Cancer Stem Cells: Constantly Evolving and Functionally Heterogeneous Therapeutic Targets

9 Apr 2014

Abstract excerpt

Elucidating the origin of and dynamic interrelationship between intratumoral cell subpopulations has clear clinical significance in helping to understand the cellular basis of treatment response, therapeutic resistance, and tumor relapse. Cancer stem cells (CSC), together with clonal evolution driven by genetic alterations, generate cancer cell heterogeneity commonly observed in clinical samples. The 2013...

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PMID: 24713433
DOI: 10.1158/0008-5472.can-14-0266

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