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Article

Cancer stem cells: current status and evolving complexities.

Cell stem cell - 14 Jun 2012

Visvader Jane E, Lindeman Geoffrey J

Abstract excerpt

The cancer stem cell (CSC) model has been established as a cellular mechanism that contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent observations, however, have highlighted many complexities and challenges: the CSC phenotype can vary substantially between patients, tumors may harbor multiple phenotypically or genetically distinct CSCs, metastatic CSCs can evolve from primary...

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PMID: 22704512
DOI: 10.1016/j.stem.2012.05.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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