Article
TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival.
Cancer science - 1 Feb 2013
Yoshida Kenya, Sato Mitsuo, Hase Tetsunari, Elshazley Momen, Yamashita Ryo, Usami Noriyasu, Taniguchi Tetsuo, Yokoi Kohei, Nakamura Shigeo, Kondo Masashi, Girard Luc, Minna John D, Hasegawa Yoshinori
Abstract excerpt
TIMELESS (TIM) is a mammalian homolog of a Drosophila circadian rhythm gene, but its circadian properties in mammals have yet to be determined. TIM appears to be essential for replication protection and genomic stability. Recently, the involvement of TIM in human malignancies has been reported; therefore, we investigated the role of TIM in lung cancer. Microarray expression analysis of lung cancer cell lines...
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