Article
Histone deacetylase inhibitor suberoylanilide hydroxamic acid suppresses the pro-oncogenic effects induced by hepatitis B virus pre-S2 mutant oncoprotein and represents a potential chemopreventive agent in high-risk chronic HBV patients.
Carcinogenesis - 1 Feb 2013
Hsieh Yi-Hsuan, Su Ih-Jen, Yen Chia-Jui, Tsai Ting-Fen, Tsai Hung-Wen, Tsai Han-Ni, Huang Yu-Jun, Chen Yen-Yu, Ai Yu-Lin, Kao Lin-Yuan, Hsieh Wen-Chuan, Wu Han-Chieh, Huang Wenya
Abstract excerpt
Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). The pre-S(2) mutant large HBV surface antigen (LHBS) in type II ground glass hepatocytes (GGHs) has been recognized as an emerging viral oncoprotein; it directly interacts with the c-Jun activation domain-binding protein 1 (JAB1) and subsequently causes hyperphosphorylation of the tumor-suppressor retinoblastoma and,...
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