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Article

DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase

19 Nov 2012

Abstract excerpt

Budding yeast cells suffering a single unrepaired double-strand break (DSB) trigger the Mec1 (ATR)-dependent DNA damage response that causes them to arrest before anaphase for 12-15 h. Here we find that hyperactivation of the cytoplasm-to-vacuole (CVT) autophagy pathway causes the permanent G2/M arrest of cells with a single DSB that is reflected in the nuclear exclusion of both Esp1 and Pds1. Transient...

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PMID: 23169651
DOI: 10.1073/pnas.1218065109

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