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Article

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

13 Nov 2019

Abstract excerpt

Since nuclear envelope breakdown occurs during mitosis in metazoan cells, it has been proposed that macroautophagy must be inhibited to maintain genome integrity. However, repression of macroautophagy during mitosis remains controversial and mechanistic detail limited to the suggestion that CDK1 phosphorylates VPS34. Here, we show that initiation of macroautophagy, measured by the translocation of the ULK complex...

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PMID: 31733992
DOI: 10.1016/j.molcel.2019.10.016

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