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Article

The DNA damage checkpoint signal in budding yeast is nuclear limited.

Molecular cell - 1 Aug 2000

Demeter J, Lee S E, Haber J E, Stearns T

Abstract excerpt

The nature of the DNA damage-induced checkpoint signal that causes the arrest of cells prior to mitosis is unknown. To determine if this signal is transmitted through the cytoplasm or is confined to the nucleus, we created binucleate heterokaryon yeast cells in which one nucleus suffered an unrepairable double-strand break, and the second nucleus was undamaged. In most of these binucleate cells, the damaged...

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Identifiers

PMID: 10983994
DOI: 10.1016/s1097-2765(00)00047-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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