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Article

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

7 Jan 2015

Abstract excerpt

(Macro)autophagy delivers cellular constituents to lysosomes for degradation. Although a cytoplasmic process, autophagy-deficient cells accumulate genomic damage, but an explanation for this effect is currently unclear. We report here that inhibition of autophagy causes elevated proteasomal activity leading to enhanced degradation of checkpoint kinase 1 (Chk1), a pivotal factor for the error-free DNA repair...

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Share to Autophagy in Disease and Therapy
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Identifiers

PMID: 25568088
DOI: 10.1073/pnas.1409563112

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