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Article

Drosophila RecQ4 is directly involved in both DNA replication and the response to UV damage in S2 cells.

PloS one - 1 Jan 2012

Crevel Gilles, Vo Nicole, Crevel Isabelle, Hamid Sana, Hoa Lily, Miyata Seiji, Cotterill Sue

Abstract excerpt

The RecQ4 protein shows homology to both the S.cerevisiae DNA replication protein Sld2 and the DNA repair related RecQ helicases. Experimental data also suggest replication and repair functions for RecQ4, but the precise details of its involvement remain to be clarified.Here we show that depletion of DmRecQ4 by dsRNA interference in S2 cells causes defects consistent with a replication function for the protein....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23166690
DOI: 10.1371/journal.pone.0049505
PMCID: PMC3500301

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila RecQ4 is directly involved in both DNA replication and the response to UV damage in S2 cells.PMID 23166690Read ↗

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Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.Semantic proximity Read ↗

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Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid ExchangesSemantic proximity Read ↗

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