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Article

RECQL4 is not critical for firing of human DNA replication origins

2 Apr 2024

Abstract excerpt

Human RECQL4, a member of the RecQ helicase family, plays a role in maintaining genomic stability, but its precise function remains unclear. The N-terminus of RECQL4 has similarity to Sld2, a protein required for the firing of DNA replication origins in budding yeast. Consistent with this sequence similarity, the Xenopus laevis homolog of RECQL4 has been implicated in initiating DNA replication in egg extracts....

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PMID: 38565932
DOI: 10.1038/s41598-024-58404-0

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