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Article

Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development.

Developmental biology - 1 Nov 2008

Wu Jianhong, Capp Christopher, Feng Liping, Hsieh Tao-shih

Abstract excerpt

Members of the RecQ family play critical roles in maintaining genome integrity. Mutations in human RecQL4 cause a rare genetic disorder, Rothmund-Thomson syndrome. Transgenic mice experiments showed that the RecQ4 null mutant causes embryonic lethality. Although biochemical evidence suggests that the Xenopus RecQ4 is required for the initiation of DNA replication in the oocyte extract, its biological functions...

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Identifiers

PMID: 18755177
DOI: 10.1016/j.ydbio.2008.08.006
PMCID: PMC2600506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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