Article
Association of CD28 and CTLA-4 gene polymorphisms with aggressive periodontitis in Brazilians.
Oral diseases - 1 Sept 2013
e Silva M R M A, Moreira P R, da Costa G C, Saraiva A M, de Souza P E A, Amormino S A F, da Costa J E, Gollob K J, Dutra W O
Abstract excerpt
OBJECTIVE: Susceptibility to and severity of periodontal disease is influenced by gene polymorphisms related to the immune response. Co-stimulatory molecules, such as CD28 and CTLA-4, are critical in the development of such responses. Our hypothesis is that polymorphisms in genes that code for these molecules may be associated with periodontitis. The aim of the study was to investigate the association between +17...
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