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Article

Mutant huntingtin impairs immune cell migration in Huntington disease.

The Journal of clinical investigation - 1 Dec 2012

Kwan Wanda, Träger Ulrike, Davalos Dimitrios, Chou Austin, Bouchard Jill, Andre Ralph, Miller Aaron, Weiss Andreas, Giorgini Flaviano, Cheah Christine, Möller Thomas, Stella Nephi, Akassoglou Katerina, Tabrizi Sarah J, Muchowski Paul J

Abstract excerpt

In Huntington disease (HD), immune cells are activated before symptoms arise; however, it is unclear how the expression of mutant huntingtin (htt) compromises the normal functions of immune cells. Here we report that primary microglia from early postnatal HD mice were profoundly impaired in their migration to chemotactic stimuli, and expression of a mutant htt fragment in microglial cell lines was sufficient to...

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Identifiers

PMID: 23160193
DOI: 10.1172/JCI64484
PMCID: PMC3533551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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