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The Role and Mechanism of TRIM Proteins in Gastric Cancer

19 Dec 2024

Abstract excerpt

Tripartite motif (TRIM) family proteins, distinguished by their N-terminal region that includes a Really Interesting New Gene (RING) domain with E3 ligase activity, two B-box domains, and a coiled-coil region, have been recognized as significant contributors in carcinogenesis, primarily via the ubiquitin-proteasome system (UPS) for degrading proteins. Mechanistically, these proteins modulate a variety of...

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Cancer Mechanisms and Therapy
interferon and immune responses
Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39768197
DOI: 10.3390/cells13242107

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