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Article

Acquired hypermethylation of the P16INK4A promoter in abdominal paraganglioma: relation to adverse tumor phenotype and predisposing mutation.

Endocrine-related cancer - 1 Feb 2013

Kiss Nimrod B, Muth Andreas, Andreasson Adam, Juhlin C Christofer, Geli Janos, Bäckdahl Martin, Höög Anders, Wängberg Bo, Nilsson Ola, Ahlman Håkan, Larsson Catharina

Abstract excerpt

Recurrent alterations in promoter methylation of tumor suppressor genes (TSGs) and LINE1 (L1RE1) repeat elements were previously reported in pheochromocytoma and abdominal paraganglioma. This study was undertaken to explore CpG methylation abnormalities in an extended tumor panel and assess possible relationships between metastatic disease and mutation status. CpG methylation was quantified by bisulfite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23154831
DOI: 10.1530/ERC-12-0267
PMCID: PMC3573842

Genes

SDHB
VHL
CDH1
RARB
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acquired hypermethylation of the P16INK4A promoter in abdominal paraganglioma: relation to adverse tumor phenotype and predisposing mutation.PMID 23154831Read ↗

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