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Article

Global and Regional CpG Methylation in Pheochromocytomas and Abdominal Paragangliomas: Association to Malignant Behavior

1 May 2008

Abstract excerpt

PURPOSE: This study aims to quantitatively assess promoter and global methylation changes in pheochromocytomas and abdominal paragangliomas and its relation to tumor phenotypes. EXPERIMENTAL DESIGN: A panel of 53 primary tumors (42 benign, 11 malignant) was analyzed by quantitative bisulfite pyrosequencing. Based on methylation levels in the tumor suppressor genes, p16(INK4A), CDH1, DCR2, RARB, RASSF1A, NORE1A,...

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Share to Adrenal and Paraganglionic Tumors
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PMID: 18451216
DOI: 10.1158/1078-0432.ccr-07-1867

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