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Article

Silver-enhanced in situ hybridization for determination of EGFR copy number alterations in non-small cell lung cancer.

The American journal of surgical pathology - 1 Dec 2012

Wulf Marie-Angela, Bode Beata, Zimmermann Dieter, Rufibach Kaspar, Weder Walter, Moch Holger, Soltermann Alex, Tischler Verena

Abstract excerpt

Epidermal growth factor receptor (EGFR) gene mutation and high gene copy number (CN) predict response to EGFR tyrosine kinase inhibitor therapy in the adenocarcinoma subtype of non-small cell lung cancer (NSCLC). The aims of this study were first to compare automated enzyme metallographic silver-enhanced in situ hybridization (SISH) with conventionally used fluorescence in situ hybridization (FISH) in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23154768
DOI: 10.1097/PAS.0b013e31826ff153

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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