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Article

EGFR gene copy number alterations are not a useful screening tool for predicting EGFR mutation status in lung adenocarcinoma.

Pathology - 1 Jan 2014

Russell Prudence A, Yu Yong, Do Hongdo, Clay Timothy D, Moore Melissa M, Wright Gavin M, Conron Matthew, Wainer Zoe, Dobrovic Alexander, McLachlan Sue-Anne

Abstract excerpt

We investigated if gene copy number (GCN) alterations of the epidermal growth factor receptor (EGFR), as detected by silver enhanced in situ hybridisation (SISH), could be used to select patients for EGFR mutation testing. Resected lung adenocarcinoma specimens with adequate tumour were identified. EGFR SISH was performed using the Ventana Benchmark Ultra platform. EGFR GCN was classified according to the...

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Identifiers

PMID: 24300726
DOI: 10.1097/PAT.0000000000000027

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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