Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.

doi:10.1016/j.lungcan.2008.01.009

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Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2008

Chang John Wen-Cheng, Liu Hui-Ping, Hsieh Meng-Heng, Fang Yueh-Fu, Hsieh Meng-Shu, Hsieh Jia-Juan, Chiu Yu-Ting, Tsai Hsien-Yu, Chen Yi-Hsuan, Chen Ya-Ting, Hsu Hui-Yu, Chen Ying-Tsong, Tsai Shih-Feng, Chen Yi-Rong, Hsi Bae-Li, Huang Shiu-Feng

Abstract excerpt

SUMMARY: To evaluate the association of epidermal growth factor receptor (EGFR) gene copy number with EGFR and k-ras mutation status and tyrosine kinase inhibitor (TKI) sensitivity in non-small cell lung cancer (NSCLC), EGFR gene copy number of 182 NSCLC tumor specimens were analyzed by chromogenic in situ hybridization (CISH). EGFR and k-ras mutation analyses were also performed for, respectively, 176 and 157 of...

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PMID: 18304690
DOI: 10.1016/j.lungcan.2008.01.009

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EGFR
CISH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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