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Rare Genetic Variants of Cell Adhesion Molecules in Transgender Men Suggest a Potential Role in Gender Dysphoria.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation - 1 Jan 2025

Onur Cura Duygu, Çankaya Tufan, Altiok Clark Özden, Aydin Leyla Rezan, Çağlayan Ahmet Okay, Ülgenalp Ayfer

Abstract excerpt

<p>Introduction: Transgender identity is a complex and multifactorial condition shaped by the effects of environmental and cultural factors as well as its biological basis. Genes involved in neurodevelopment and neuroplasticity may contribute to brain sexual differentiation, and rare variants in these genes could play a role in gender diversity. This study aimed to enhance explanations for the genetic component...

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Identifiers

PMID: 41208545
DOI: 10.1159/000549011
PMCID: PMC12674652

Genes

GOLGA8J
PCDHA8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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