Article
Loss-of-function mutations in filaggrin gene associate with psoriasis vulgaris in Chinese population.
Human genetics - 1 Jul 2012
Hu Zhengmao, Xiong Zhimin, Xu Xiaojuan, Li Fangfang, Lu Lina, Li Wei, Su Juan, Liu Yalan, Liu Deyuan, Xie Zhiguo, Peng Yu, Kuang Yehong, Wu Lisha, Zhang Jianglin, Pan Qian, Tang Beisha, Chen Xiang, Xia Kun
Abstract excerpt
Loss-of-function mutations in filaggrin gene (FLG; OMIM #135940) have been reported to cause the semi-dominant keratinizing disorders such as ichthyosis vulgaris (IV; OMIM #146700) and atopic dermatitis (AD; OMIM #605803). Recent linkage analysis and immunohistochemical studies suggest the possible contribution of FLG to psoriatic susceptibility. However, no susceptibility variant in FLG gene associated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.