Article
14q deletions are associated with trisomy 12, NOTCH1 mutations and unmutated IGHV genes in chronic lymphocytic leukemia and small lymphocytic lymphoma.
Genes, chromosomes & cancer - 1 Aug 2014
Cosson Adrien, Chapiro Elise, Belhouachi Nabila, Cung Hong-Anh, Keren Boris, Damm Frederik, Algrin Caroline, Lefebvre Christine, Fert-Ferrer Sandra, Luquet Isabelle, Gachard Nathalie, Mugneret Francine, Terre Christine, Collonge-Rame Marie-Agnes, Michaux Lucienne, Rafdord-Weiss Isabelle, Talmant Pascaline, Veronese Lauren, Nadal Nathalie, Struski Stephanie, Barin Carole, Helias Catherine, Lafage Marina, Lippert Eric, Auger Nathalie, Eclache Virginie, Roos-Weil Damien, Leblond Veronique, Settegrana Catherine, Maloum Karim, Davi Frederic, Merle-Beral Helene, Lesty Claude, Nguyen-Khac Florence
Abstract excerpt
Deletions of the long arm of chromosome 14 [del(14q)] are rare but recurrently observed in mature B-cell neoplasms, particularly in chronic lymphocytic leukemia (CLL). To further characterize this aberration, we studied 81 cases with del(14q): 54 of CLL and 27 of small lymphocytic lymphoma (SLL), the largest reported series to date. Using karyotype and fluorescence in situ hybridization (FISH), the most frequent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.