Article
Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance.
Cell research - 1 Feb 2009
Kai Yoshiteru, Wang Chi Chiu, Kishigami Satoshi, Kazuki Yasuhiro, Abe Satoshi, Takiguchi Masato, Shirayoshi Yasuaki, Inoue Toshiaki, Ito Hisao, Wakayama Teruhiko, Oshimura Mitsuo
Abstract excerpt
Although particular chromosomal syndromes are phenotypically and clinically distinct, the majority of individuals with autosomal imbalance, such as aneuploidy, manifest mental retardation. A common abnormal phenotype of Down syndrome (DS), the most prevalent autosomal aneuploidy, shows a reductio...
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