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Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia

4 Feb 2014

Abstract excerpt

Distinct patterns of DNA methylation characterize the epigenetic landscape of promyelocytic leukemia/retinoic acid receptor-α (PML-RARα)-associated acute promyelocytic leukemia (APL). We previously reported that the microRNAs (miRNAs) clustered on chromosome 14q32 are overexpressed only in APL. Here, using high-throughput bisulfite sequencing, we identified an APL-associated hypermethylation at the upstream...

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PMID: 24493669
DOI: 10.1182/blood-2012-12-469833

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