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Article

Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2010

Kiechl Stefan, Laxton Ross C, Xiao Qingzhong, Hernesniemi Jussi A, Raitakari Olli T, Kähönen Mika, Mayosi Bongani M, Jula Antti, Moilanen Leena, Willeit Johann, Watkins Hugh, Samani Nilesh J, Lehtimäki Terho J, Keavney Bernard, Xu Qingbo, Ye Shu

Abstract excerpt

OBJECTIVE: To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated with stromal cell-derived factor-1α (SDF-1α) plasma levels. METHODS AND RESULTS: Variation on chromosome 10q11.21 has been consistently associated with coronary artery disease. The genetic variant lies upstream of the gene encoding SDF-1α. We genotyped 3...

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PMID: 20847302
DOI: 10.1161/ATVBAHA.110.213785

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