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Rescue of Auditory Function by a Single Administration of AAV- <i>TMPRSS3</i> Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8

2023-02-26

Abstract excerpt

<h4>Abstracts</h4> Patients with mutations in the TMPRSS3 gene suffer from recessive deafness DFNB8/DFNB10 for whom cochlear implantation is the only treatment option. Poor cochlear implantation outcomes are seen in some patients. To develop biological treatment for TMPRSS3 patients, we generated a knock-in mouse model with a frequent human DFNB8 TMPRSS3 mutation. The Tmprss3 A306T/A306T homozygous mice displa...

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Literature Corpus work
705da94d-ea0a-5b03-9304-edb9bbde61e7
DOI
10.1101/2023.02.25.530035
Open publication

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Rescue of Auditory Function by a Single Administration of AAV- <i>TMPRSS3</i> Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8DOI 10.1101/2023.02.25.530035
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