Defects in hair cells disrupt the development of auditory peripheral circuitry.

Abstract excerpt

Deafness is the most common form of sensory impairment in humans and frequently caused by defects in hair cells of the inner ear. Here we demonstrate that in male mice which model recessive non-syndromic deafness (DFNB6), inactivation of Tmie in hair cells disrupts gene expression in the neurons that innervate them. This includes genes regulating axonal pathfinding and synaptogenesis, two processes that are...

Topics

• Animals
• Hair Cells, Auditory
• Male
• Mice
• Deafness
• Disease Models, Animal
• Genetic Therapy
• Mutation
• Humans
• Ear, Inner