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Article

Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.

The Journal of biological chemistry - 4 Jan 2013

Yu Junjing, He Xiaomeng, Chen Ye-Guang, Hao Yan, Yang Shuo, Wang Lei, Pan Lei, Tang Hong

Abstract excerpt

Bone morphogenetic proteins (BMPs) signaling essentially regulates a wide range of biological responses. Although multiple regulators at different layers of the receptor-effectors axis have been identified, the mechanisms of homeostatic BMP signaling remain vague. Herein we demonstrated that myotubularin-related protein 4 (MTMR4), a FYVE domain-containing dual-specificity protein phosphatase (DUSP),...

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Identifiers

PMID: 23150675
DOI: 10.1074/jbc.M112.413856
PMCID: PMC3537074

Genes

MTMR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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