Article
Epigenetics and epigenetic mechanisms in disease with emphasis on autoimmune diseases.
The Journal of the Association of Physicians of India - 1 Nov 2008
Krupanidhi S, Sedimbi S K, Sanjeevi C B
Abstract excerpt
Epigenetics deals with molecular heritable patterns relating to chromatin, which exists in two alterable and inter-convertible states. The two conformations of chromatin i.e., compact and relaxed are due to epigenetic regulation. The alterations in chromatin normalize gene expression patterns. Thus, the epigenetic marks on chromatin are the deciding factors for either gene silencing or activation. The epigenetics...
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