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Article

Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.

Epigenomics - 1 Apr 2012

Butler Jill S, Koutelou Evangelia, Schibler Andria C, Dent Sharon Y R

Abstract excerpt

Precise transcriptional networks drive the orchestration and execution of complex developmental processes. Transcription factors possessing sequence-specific DNA binding properties activate or repress target genes in a step-wise manner to control most cell lineage decisions. This regulation often requires the interaction between transcription factors and subunits of massive protein complexes that bear enzymatic...

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Identifiers

PMID: 22449188
DOI: 10.2217/epi.12.3
PMCID: PMC3382990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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