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Article

Preexisting epithelial diversity in normal human livers: a tissue-tethered cytometric analysis in portal/periportal epithelial cells.

Hepatology (Baltimore, Md.) - 1 Apr 2013

Isse Kumiko, Lesniak Andrew, Grama Kedar, Maier John, Specht Susan, Castillo-Rama Marcela, Lunz John, Roysam Badrinath, Michalopoulos George, Demetris Anthony J

Abstract excerpt

UNLABELLED: Routine light microscopy identifies two distinct epithelial cell populations in normal human livers: hepatocytes and biliary epithelial cells (BECs). Considerable epithelial diversity, however, arises during disease states when a variety of hepatocyte-BEC hybrid cells appear. This has been attributed to activation and differentiation of putative hepatic progenitor cells (HPC) residing in the canals of...

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PMID: 23150208
DOI: 10.1002/hep.26131
PMCID: PMC3612393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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