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Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

26 Jul 2019

Abstract excerpt

Abstract The liver parenchyma is composed of hepatocytes and bile duct epithelial cells (BECs). Controversy exists regarding the cellular origin of human liver parenchymal tissue generation during embryonic development, homeostasis or repair. Here we report the existence of a hepatobiliary hybrid progenitor (HHyP) population in human foetal liver using single-cell RNA sequencing. HHyPs are anatomically restricted...

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PMID: 31350390
DOI: 10.1038/s41467-019-11266-x

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