Article
From a common progenitor to distinct liver epithelial phenotypes.
Current opinion in cell biology - 1 Oct 2018
Müsch Anne
Abstract excerpt
The vertebrate liver presents a fascinating case study for how cell form is optimized for function. To execute its duties the liver assembles two distinct lumen-forming epithelial phenotypes: Firstly, cords with a branched, capillary-like luminal network formed between hepatocytes (bile canaliculi); and secondly, tubular ducts formed by biliary epithelial cells arranged around a central cavity and connected to...
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