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Article

Clinical impact of genetically determined platelet reactivity.

Journal of cardiovascular translational research - 1 Jun 2013

Laine Marc, Arméro Sébastien, Peyrol Michaël, Sbragia Pascal, Thuny Franck, Paganelli Franck, Bonello Laurent

Abstract excerpt

Dual antiplatelet therapy with aspirin and clopidogrel dramatically reduced the rate of major adverse cardiac events following percutaneous coronary intervention. Clopidogrel is a prodrug which requires a two-step hepatic biotransformation thanks to the cytochrome P450 (CYP450) enzyme system. Genetic polymorphism of CYP450 system (e.g., CYP2C19*2) responsible for altered clopidogrel metabolism is a major cause of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23149816
DOI: 10.1007/s12265-012-9421-4

Genes

ABCB1
TIAM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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