Article
Pharmacogenetics of clopidogrel.
Current pharmaceutical design - 1 Jan 2012
O'Connor Stephen A, Hulot Jean-Sebastien, Silvain Johanne, Cayla Guillaume, Montalescot Gilles, Collet Jean-Philippe
Abstract excerpt
Clopidogrel used in conjunction with aspirin has a central role in the treatment of patients with an acute coronary syndrome (ACS) and/or undergoing percutaneous coronary intervention (PCI). The pharmacokinetic and pharmacodynamic responses to this drug are highly variable leaving up to one third of patients with inadequate platelet inhibition or high on-treatment platelet reactivity (HPR), and subsequent...
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