Negative predictive value of IL28B, SLC28A2, and CYP27B1 SNPs and low RBV plasma exposure for therapeutic response to PEG/IFN-RBV treatment.

doi:10.1097/FTD.0b013e318272e55a

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Article

Negative predictive value of IL28B, SLC28A2, and CYP27B1 SNPs and low RBV plasma exposure for therapeutic response to PEG/IFN-RBV treatment.

Therapeutic drug monitoring - 1 Dec 2012

D'Avolio Antonio, Ciancio Alessia, Siccardi Marco, Smedile Antonina, Simiele Marco, Cusato Jessica, Baietto Lorena, Aguilar Marucco Diego, Cariti Giuseppe, Calcagno Andrea, Gonzalez de Requena Daniel, Sciandra Mauro, Troshina Giulia, Caviglia Gian Paolo, Bonora Stefano, Rizzetto Mario, Di Perri Giovanni

Abstract excerpt

OBJECTIVES: The response rate to treatment of chronic hepatitis C virus-genotype 1 and 4 infections was recently found to be strongly influenced by many polymorphisms. The aim of our study was to carry out an integrated analysis of the effects of polymorphisms and ribavirin (RBV) plasma exposure on outcome. METHODS: The retrospective analysis included 174 patients. IL28B, CYP27B1, SLC29A1, SLC28A3, and SLC28A2...

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PMID: 23149444
DOI: 10.1097/FTD.0b013e318272e55a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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