Article
Pretreatment prediction of the outcome of response-guided peginterferon-α and ribavirin therapy for chronic hepatitis C.
Journal of gastroenterology and hepatology - 1 Dec 2014
Masaki Naohiko, Sugiyama Masaya, Shimada Noritomo, Tanaka Yasuhito, Nakamuta Makoto, Izumi Namiki, Watanabe Sumio, Tsubota Akihito, Komatsu Masafumi, Masaki Tsutomu, Enomoto Nobuyuki, Yoneda Masashi, Murata Kazumoto, Ito Kiyoaki, Koike Kazuhiko, Mizokami Masashi
Abstract excerpt
BACKGROUND AND AIM: The accuracy for predicting virological outcomes of peginterferon-α and ribavirin therapy in patients with chronic hepatitis C is limited to approximately 80%, even with IL28B genotyping. Our in vitro study revealed that the numbers of (TA) dinucleotide repeats [(TA)n] of rs72258881, which is located in the promoter region of IL28B gene, might regulate IL28B transcription. We aimed to evaluate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.