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Article

Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight.

Epigenetics - 1 Feb 2012

Pidsley Ruth, Dempster Emma, Troakes Claire, Al-Sarraj Safa, Mill Jonathan

Abstract excerpt

IGF2 is a paternally expressed imprinted gene with an important role in development and brain function. Allele-specific expression of IGF2 is regulated by DNA methylation at three differentially methylated regions (DMRs) spanning the IGF2/H19 domain on human 11p15.5. We have comprehensively assessed DNA methylation and genotype across the three DMRs and the H19 promoter using tissue from a unique collection of...

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Share to Cerebellum
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Like Growth Factor II

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Source

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Identifiers

PMID: 22395465
DOI: 10.4161/epi.7.2.18910
PMCID: PMC3335909

Genes

IGF2
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight.PMID 22395465Read ↗

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Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders.Semantic proximity Read ↗

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