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Article

The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.

Molecular and cellular endocrinology - 15 Dec 2010

Zheng Weiming, Horton Cheryl D, Kim Jonathan, Halvorson Lisa M

Abstract excerpt

Normal sexual development and reproductive function depend on precise temporal and quantitative expression of the pituitary gonadotropins, LH and FSH. LHβ-subunit gene expression is achieved by transcription factors acting at highly conserved and closely spaced cis-elements in the proximal 200 base pairs of the promoter. We now demonstrate that LHβ promoter activity is further regulated by the orphan nuclear...

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PMID: 20797425
DOI: 10.1016/j.mce.2010.08.010

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