Article
Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB.
PloS one - 1 Jan 2012
Camperio Cristina, Caristi Silvana, Fanelli Giorgia, Soligo Marzia, Del Porto Paola, Piccolella Enza
Abstract excerpt
Considerable evidence supports the prediction that CD25 is directly regulated by the forkhead transcription factor FOXP3. However, given that CD25 is normally upregulated in activated T cells, regardless of whether they express FOXP3, this issue has still to be definitively demonstrated. Here we describe that FOXP3, induced by CD28 signals in human CD4(+)CD25(-) T lymphocytes, synergizes with RelA on a regulatory...
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