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Article

Antibiotic-Mediated Selection of Quorum-Sensing-Negative Staphylococcus aureus

11 Nov 2012

Abstract excerpt

UNLABELLED: Staphylococcus aureus is a human commensal that at times turns into a serious bacterial pathogen causing life-threatening infections. For the delicate control of virulence, S. aureus employs the agr quorum-sensing system that, via the intracellular effector molecule RNAIII, regulates virulence gene expression. We demonstrate that the presence of the agr locus imposes a fitness cost on S. aureus that...

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PMID: 23143800
DOI: 10.1128/mbio.00459-12

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