Article
Identification of mutations in the NUCB2/nesfatin gene in children with severe obesity.
Molecular genetics and metabolism - 1 Dec 2012
Zegers Doreen, Beckers Sigri, de Freitas Fenna, Jennes Karen, Van Camp Jasmijn K, Mertens Ilse L, Van Hoorenbeeck Kim, Rooman Raoul P, Desager Kristine N, Massa Guy, Van Gaal Luc F, Van Hul Wim
Abstract excerpt
Nesfatin-1 is the N-terminal fragment of nucleobindin-2 (NUCB2) that was identified as a novel satiety molecule in rodents. The protein is reported to exert anorexigenic effects and appears to play an important role in hypothalamic pathways regulating energy homeostasis and food intake. In this study, we hypothesized that mutations in the nesfatin encoding gene NUCB2 might cause obesity in humans. Therefore, we...
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